The Earth Science Applications Guidebook is a web-based, multimedia product that synthesizes best practices and lessons learned on the use of Earth science information for decision-making. It is also available as a PDF document. Drawing on a wealth of knowledge and the passion of scientists who have dedicated their careers to Earth science, the guidebook taps into decades of experience in addressing climate change, biodiversity, disaster management, and other challenges. The guidebook offers both emerging and experienced scientists’ practical guidance on applications to solve pressing problems and improve people’s lives.